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1

Evaluation of the systemic toxicity and pharmacokinetics of the immunoconjugate anti-B4-blocked ricin in non-human primates. Delivered by multiple bolus injections and by continuous infusion

Sudhir A. Shah, John M. Lambert, Victor S. Goldmacher, Henry J. Esber, James L. Levin, Vinod Chungi, Anup Zutshi, Ginny M. Braman, Pamela D. Ariniello, James A. Taylor, Walter A. Blättler

Journal:

International Journal of Immunopharmacology

Year:

1993

Language:

english

File:

PDF, 1.12 MB

english, 1993

2

Anti-CD6-blocked ricin: An anti-pan T-cell immunotoxin

Albert R. Collinson, John M. Lambert, Yimao Liu, Conor O'Dea, Sudhir A. Shah, Robert A. Rasmussen, Victor S. Goldmacher

Journal:

International Journal of Immunopharmacology

Year:

1994

Language:

english

File:

PDF, 968 KB

english, 1994

3

Cell killing by antibody–drug conjugates

Yelena V. Kovtun, Victor S. Goldmacher

Journal:

Year:

2007

Language:

english

File:

PDF, 458 KB

english, 2007

4

The effect of the cell death suppressor vMIA on the production of a recombinant protein in the adenovirus-293 expression system

Helena L.A. Vieira, Liliana Cunha, Victor S. Goldmacher, Paula M. Alves

Journal:

Protein Expression and Purification

Year:

2009

Language:

english

File:

PDF, 455 KB

english, 2009

5

Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates

Zhao, Robert Y., Wilhelm, Sharon D., Audette, Charlene, Jones, Gregory, Leece, Barbara A., Lazar, Alexandru C., Goldmacher, Victor S., Singh, Rajeeva, Kovtun, Yelena, Widdison, Wayne C., Lambert, John

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.26 MB

english, 2011

6

Conjugation of Blocked Ricin to an Anti-CD19 Monoclonal Antibody Increases Antibody-Induced Cell Calcium Mobilization and CD19 Internalization

Goulet, Anne-Christine, Goldmacher, Victor S., Lambert, John M., Baron, Chantal, Roy, Denis-Claude, Kouassi, Edouard

Journal:

Year:

1997

File:

PDF, 452 KB

1997

7

Folate-maytansinoids: Target-selective drugs of low molecular weight

Cynthia A. Ladino, Ravi V.J. Chari, Lizabeth A. Bourret, Nancy L. Kedersha, Victor S. Goldmacher

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 154 KB

english, 1997

8

Synthesis and Biological Evaluation of Novel Taxoids Designed for Targeted Delivery to Tumors.

Erkan Baloglu, Michael L. Miller, Elizabeth E. Roller, Emily E. Cavanagh, Barbara A. Leece, Victor S. Goldmacher, Ravi V. J. Chari

Journal:

Year:

2005

File:

PDF, 16 KB

2005

9

Internalization of glycosyl-phosphatidylinositol (GPI)-anchored lymphocyte proteins II. GPI-anchored and transmembrane molecules internalize through distinct pathways

Anil Bamezai, Victor S. Goldmacher, Kenneth L. Rock

Journal:

European Journal of Immunology

Year:

1992

Language:

english

File:

PDF, 634 KB

english, 1992

10

Cytotoxicity of gelonin and its conjugates with antibodies is determined by the extent of their endocytosis

Victor S. Goldmacher, Charles F. Scott, John M. Lambert, Gordon D. McIntyre, Walter A. Blättler, Albert R. Collinson, Jean K. Stewart, Lisa D. Chong, Sherrilyn Cook, Henry S. Slayter, Elisabeth Beaumo

Journal:

Journal of Cellular Physiology

Year:

1989

Language:

english

File:

PDF, 1.66 MB

english, 1989

11

The pharmacokinetics and toxicity of murine monoclonal antibodies and of gelonin conjugates of these antibodies

Charles F. Scott Jr., John M. Lambert, Victor S. Goldmacher, Walter A. Blattler, Raymond Sobel, Stuart F. Schlossman, Baruj Benacerraf

Journal:

International Journal of Immunopharmacology

Year:

1987

Language:

english

File:

PDF, 1.76 MB

english, 1987

12

Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors

Erkan Baloglu, Michael L. Miller, Elizabeth E. Roller, Emily E. Cavanagh, Barbara A. Leece, Victor S. Goldmacher, Ravi V.J. Chari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

13

The antileukemic efficacy of an immunotoxin composed of a monoclonal anti-Thy-1 antibody disulfide linked to the ribosome-inactivating protein gelonin

Charles F. Scott, Victor S. Goldmacher, John M. Lambert, Ravi V. J. Chari, Susan Bolender, Michael N. Gauthier, Walter A. Blättler

Journal:

Cancer Immunology, Immunotherapy

Year:

1987

Language:

english

File:

PDF, 1.14 MB

english, 1987

14

The murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization

Damien Arnoult, Anna Skaletskaya, Jérôme Estaquier, Cecilie Dufour, Victor S. Goldmacher

Journal:

Year:

2008

Language:

english

File:

PDF, 620 KB

english, 2008

15

Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies

Michael L Miller, Elizabeth E Roller, Xinyaun Wu, Barbara A Leece, Victor S Goldmacher, Ravi V.J Chari, Iwao Ojima

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 284 KB

english, 2004

16

Targeting CD56 by the maytansinoid immunoconjugate IMGN901 (huN901-DM1): a potential therapeutic modality implication against natural killer/T cell malignancy

Kenji Ishitsuka, Shiro Jimi, Victor S. Goldmacher, Olga Ab, Kazuo Tamura

Journal:

British Journal of Haematology

Year:

2008

Language:

english

File:

PDF, 90 KB

english, 2008

17

The Sequence and Antiapoptotic Functional Domains of the Human Cytomegalovirus UL37 Exon 1 Immediate Early Protein Are Conserved in Multiple Primary Strains

Wail A. Hayajneh, Anamaris M. Colberg-Poley, Anna Skaletskaya, Laura M. Bartle, Marci M. Lesperance, Despina G. Contopoulos-Ioannidis, Nancy L. Kedersha, Victor S. Goldmacher

Journal:

Year:

2001

Language:

english

File:

PDF, 164 KB

english, 2001

18

Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses

A.Louise McCormick, Anna Skaletskaya, Peter A Barry, Edward S Mocarski, Victor S Goldmacher

Journal:

Year:

2003

Language:

english

File:

PDF, 673 KB

english, 2003

19

The specific cytotoxicity of immunoconjugates containing blocked ricin is dependent on the residual binding capacity of blocked ricin: Evidence that the membrane binding and A-chain translocation activities of ricin cannot be separated

Victor S. Goldmacher, John M. Lambert, Walter A. Blättler

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 580 KB

english, 1992

20

Immobilization of protein molecules on liposomes: Anchorage by artificially bound unsaturated hydrocarbon tails

Victor S. Goldmacher

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 367 KB

english, 1983

21

Macrophages: Inhibition of endocytosis by anchorage to substrate

Victor S. Goldmacher

Journal:

Experimental Cell Research

Year:

1984

Language:

english

File:

PDF, 292 KB

english, 1984

22

vMIA, a viral inhibitor of apoptosis targeting mitochondria

Victor S Goldmacher

Journal:

Year:

2002

Language:

english

File:

PDF, 269 KB

english, 2002

23

Synthesis and Biological Evaluation of Antibody Conjugates of Phosphate Prodrugs of Cytotoxic DNA Alkylators for the Targeted Treatment of Cancer

Zhao, Robert Yongxin, Erickson, Hans K., Leece, Barbara A., Reid, Emily E., Goldmacher, Victor S., Lambert, John M., Chari, Ravi V. J.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

24

A cytotoxicity assay utilizing a fluorescent dye that determines accurate surviving fractions of cells

James R. Sellers, Sherrilyn Cook, Victor S. Goldmacher

Journal:

Journal of Immunological Methods

Year:

1994

Language:

english

File:

PDF, 735 KB

english, 1994

25

Formaldehyde is mutagenic for cultured human cells

Victor S. Goldmacher, William G. Thilly

Journal:

Mutation Research/Genetic Toxicology

Year:

1983

Language:

english

File:

PDF, 319 KB

english, 1983

26

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 47 Volume 47 || Antibody–Drug Conjugates for Targeted Cancer Therapy

Goldmacher, Victor S.

Year:

2012

Language:

english

File:

PDF, 481 KB

english, 2012

27

Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates

Ojima, Iwao, Geng, Xudong, Wu, Xinyuan, Qu, Chuanxing, Borella, Christopher P., Xie, Hongsheng, Wilhelm, Sharon D., Leece, Barbara A., Bartle, Laura M., Goldmacher, Victor S., Chari, Ravi V. J.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

28

Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer

Widdison, Wayne C., Wilhelm, Sharon D., Cavanagh, Emily E., Whiteman, Kathleen R., Leece, Barbara A., Kovtun, Yelena, Goldmacher, Victor S., Xie, Hongsheng, Steeves, Rita M., Lutz, Robert J., Zhao, Ro

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 323 KB

english, 2006

29

Expression and secretion of a recombinant ricin immunotoxin from murine myeloma cells

Krek, Corinne E., Ladino, Cynthia A., Goldmacher, Victor S., Blättler, Walter A., Guild, Braydon C.

Journal:

Protein Engineering Design and Selection

Year:

1995

Language:

english

File:

PDF, 2.55 MB

english, 1995

30

Eradication of Large Colon Tumor Xenografts by Targeted Delivery of Maytansinoids

Changnian Liu, B. Mitra Tadayoni, Lizabeth A. Bourret, Kristin M. Mattocks, Susan M. Derr, Wayne C. Widdison, Nancy L. Kedersha, Pamela D. Ariniello, Victor S. Goldmacher, John M. Lambert, Walter A. B

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.35 MB

english, 1996

31

A Cytomegalovirus-Encoded Mitochondria-Localized Inhibitor of Apoptosis Structurally Unrelated to Bcl-2

Victor S. Goldmacher, Laura M. Bartle, Anna Skaletskaya, Cheryl A. Dionne, Nancy L. Kedersha, Carol A. Vater, Jia-wen Han, Robert J. Lutz, Shinya Watanabe, Ellen D. Cahir McFarland, Elliott D. Kieff,

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.50 MB

english, 1999

32

Evidence That Pinocytosis in Lymphoid Cells Has a Low Capacity

Victor S. Goldmacher, Nancy L. Tinnel and Brad C. Nelson

Journal:

The Journal of Cell Biology

Year:

1986

Language:

english

File:

PDF, 1.81 MB

english, 1986

33

Mutational and structural analysis of the lectin activity in binding domain 2 of ricin B chain

Lehar, Sophie M., Pedersen, Jan T., Kamath, Ravi S., Swimmer, Candace, Goldmacher, Victor S., Lambert, John M., Blättler, Walter A., Guild, Braydon C.

Journal:

Protein Engineering Design and Selection

Year:

1994

Language:

english

File:

PDF, 1.86 MB

english, 1994

34

The galactose-binding sites of the cytotoxic lectin ricin can be chemically blocked in high yield with reactive ligands prepared by chemical modification of glycopeptides containing triantennary N-linked oligosaccharides

Lambert, John M., McIntyre, Gail, Gauthier, Michael N., Zullo, David, Rao, Vikram, Steeves, Rita M., Goldmacher, Victor S., Blattler, Walter A.

Journal:

Year:

1991

Language:

english

File:

PDF, 2.28 MB

english, 1991

35

Modification of the binding site(s) of lectins by an affinity column carrying an activated galactose-terminated ligand

Moroney, Simon E., D'Alarcao, Linda J., Goldmacher, Victor S., Lambert, John M., Blattler, Walter A.

Journal:

Year:

1987

Language:

english

File:

PDF, 1.76 MB

english, 1987

36

Synthesis of Taxoids with Improved Cytotoxicity and Solubility for Use in Tumor-Specific Delivery

Miller, Michael L., Roller, Elizabeth E., Zhao, Robert Y., Leece, Barbara A., Ab, Olga, Baloglu, Erkan, Goldmacher, Victor S., Chari, Ravi V. J.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 71 KB

english, 2004

37

Photoactivation of toxin conjugates

Goldmacher, Victor S., Senter, Peter D., Lambert, John M., Blattler, Walter A.

Journal:

Bioconjugate Chemistry

Year:

1992

Language:

english

File:

PDF, 491 KB

english, 1992

38

Statistics of the Distribution of the Abundance of Molecules with Various Drug Loads in Maytansinoid Antibody–Drug Conjugates

Goldmacher, Victor S., Amphlett, Godfrey, Wang, Lintao, Lazar, Alexandru C.

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 580 KB

english, 2015

39

Antibody–drug conjugates: using monoclonal antibodies for delivery of cytotoxic payloads to cancer cells

Goldmacher, Victor S, Kovtun, Yelena V

Journal:

Therapeutic Delivery

Year:

2011

Language:

english

File:

PDF, 1006 KB

english, 2011

40

Humanization of Murine Monoclonal Antibodies Through Variable Domain Resurfacing

Michael A. Roguska, Jan T. Pedersen, Christine A. Keddy, Andrew H. Henry, Stephen J. Searle, John M. Lambert, Victor S. Goldmacher, Walter A. Blattler, Anthony R. Rees and Braydon C. Guild

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.21 MB

english, 1994

41

High-Affinity Accumulation of a Maytansinoid in Cells via Weak Tubulin Interaction

Goldmacher, Victor S., Audette, Charlene A., Guan, Yinghua, Sidhom, Eriene-Heidi, Shah, Jagesh V., Whiteman, Kathleen R., Kovtun, Yelena V., Komarova, Yulia

Journal:

Year:

2015

Language:

english

File:

PDF, 2.27 MB

english, 2015

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